发明申请
US20120301551A1 COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION
审中-公开
用于治疗神经性死亡或神经性功能障碍的化合物和组合物
- 专利标题： COMPOUNDS AND COMPOSITIONS FOR TREATING NEURONAL DEATH OR NEUROLOGICAL DYSFUNCTION
- 专利标题（中）： 用于治疗神经性死亡或神经性功能障碍的化合物和组合物
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申请号： US13531366申请日： 2012-06-22
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公开(公告)号： US20120301551A1公开(公告)日： 2012-11-29
- 发明人: Byoung Joo GWAG , Young Ae Lee , Jin Hee Shin , Sung Ig Cho , Jae Sung Noh , Jae Young Cho , Ki Won Kim , Hyang Ran Lim , Jae Keun Lee , Han Yeol Byun , Sun Young Ko , Sun Joo Son , Sun Mi Park
- 申请人： Byoung Joo GWAG , Young Ae Lee , Jin Hee Shin , Sung Ig Cho , Jae Sung Noh , Jae Young Cho , Ki Won Kim , Hyang Ran Lim , Jae Keun Lee , Han Yeol Byun , Sun Young Ko , Sun Joo Son , Sun Mi Park
- 申请人地址： KR Suwon-si
- 专利权人： Neurotech Pharmaceuticals Co., Ltd.
- 当前专利权人： Neurotech Pharmaceuticals Co., Ltd.
- 当前专利权人地址： KR Suwon-si
- 优先权： KR10-2005-0078028 20050824
- 主分类号： A61K33/00
- IPC分类号： A61K33/00 ; A61K31/609 ; A61P25/16 ; A61P25/00 ; A61P27/02 ; A61P25/28 ; A61P27/06 ; A61K31/195
摘要：
The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), spinal muscular atrophy, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, traumatic brain injury or spinal cord injury; and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.
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