Provided are amphiphobic block copolymers, methods for preparing amphiphobic block copolymers, and applications thereof. Amphiphobic block copolymers can be used to prepare amphiphobic coatings on material surfaces, such as glass, printing paper or fabric. Amphiphobic block copolymers can also be used to coat particles, e.g., silica nanoparticles, which are then used to coat material surfaces. Such coated particles and uses thereof are also provided herein.