发明申请
US20120264736A1 BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS
有权
苯并呋喃酮，噻吗啉，四氢萘酮和相关的游离氨基酸酶抑制剂
- 专利标题： BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS
- 专利标题（中）： 苯并呋喃酮，噻吗啉，四氢萘酮和相关的游离氨基酸酶抑制剂
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申请号： US13267324申请日： 2011-10-06
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公开(公告)号： US20120264736A1公开(公告)日： 2012-10-18
- 发明人: Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Ann Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
- 申请人： Theodros Asberom , Thomas A. Bara , Chad E. Bennett , Duane A. Burnett , Mary Ann Caplen , John W. Clader , David J. Cole , Martin S. Domalski , Hubert B. Josien , Chad E. Knutson , Hongmei Li , Mark D. McBriar , Dmitri A. Pissarnitski , Li Qiang , Murali Rajagopalan , Thavalakulamgara K. Sasikumar , Jing Su , Haiqun Tang , Wen-Lian Wu , Ruo Xu , Zhiqiang Zhao
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 主分类号： A61K31/352
- IPC分类号： A61K31/352 ; C07D409/12 ; A61K31/381 ; C07D405/12 ; A61K31/4433 ; A61K31/496 ; C07D487/08 ; A61K31/4995 ; C07D405/14 ; A61K31/4545 ; C07D413/08 ; A61K31/5377 ; C07D493/04 ; C07D491/052 ; A61P25/28 ; C07D311/80
摘要：
This invention discloses novel gamma secretase inhibitors of the formula: R2 and R3, or R2 and R4, or R3 and R4, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
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