发明申请
US20120209002A1 PROCESS FOR REDUCING THE 6-KETO GROUP OF A MORPHINAN ALKALOID TO THE 6-HYDROXY GROUP BY HYDROGENATION
有权
通过氢化将6-羟基苯甲酸的6-KETO基团还原成6-羟基的方法
- 专利标题： PROCESS FOR REDUCING THE 6-KETO GROUP OF A MORPHINAN ALKALOID TO THE 6-HYDROXY GROUP BY HYDROGENATION
- 专利标题（中）： 通过氢化将6-羟基苯甲酸的6-KETO基团还原成6-羟基的方法
-
申请号： US13390818申请日： 2010-08-13
-
公开(公告)号： US20120209002A1公开(公告)日： 2012-08-16
- 发明人: George Scott Wilson , Maureen Joan Young
- 申请人： George Scott Wilson , Maureen Joan Young
- 申请人地址： GB London
- 专利权人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- 当前专利权人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY
- 当前专利权人地址： GB London
- 优先权： GB0914338.9 20090817
- 国际申请： PCT/GB10/51343 WO 20100813
- 主分类号： C07D489/08
- IPC分类号： C07D489/08 ; C07D489/02
摘要：
The present invention relates to a process for the reduction of a 6-keto group in a morphinan alkaloid to the corresponding 6-hydroxy group, comprising hydrogenating the 6-keto group using gaseous hydrogen in the presence of a heterogenous catalyst and a solvent, to yield the 6-hydroxy morphinan alkaloid, wherein the reduction is carried out at a pH in the range of about 5 to about 7, and the 6-hydroxy morphinan alkaloid has an α:β ratio of >85:15.
公开/授权文献
信息查询
