发明申请
- 专利标题： Heteroaryl Compounds as PIKK Inhibitors
- 专利标题（中）： 杂芳基化合物作为PIKK抑制剂
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申请号： US13319683申请日： 2010-05-12
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公开(公告)号： US20120190666A1公开(公告)日： 2012-07-26
- 发明人: Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
- 申请人： Christiane Bode , Alessandro Boezio , Alan C. Cheng , Deborah Choquette , James Robert Coats , Katrina Woodin Copeland , Hongbing Huang , Daniel La , Richard Thomas Lewis , Hongyu Liao , Michele Potashman , John Stellwagen , Shuyan Yi , Mark H. Norman , Markian M. Stec , Emily Anne Peterson , Russell Graceffa
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 国际申请： PCT/US10/34596 WO 20100512
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; C07D401/14 ; A61K31/506 ; A61P35/02 ; A61K31/53 ; C07D487/04 ; A61K31/5377 ; A61P35/00 ; C07D473/40 ; C07D471/04
摘要：
The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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