发明申请
- 专利标题： Glycan Markers as Measure of Disease State of Hepatic Diseases
- 专利标题（中）： 糖标记作为肝病疾病状态的测量
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申请号： US13384031申请日： 2010-07-12
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公开(公告)号： US20120190576A1公开(公告)日： 2012-07-26
- 发明人: Hisashi Narimatsu , Jun Hirabayashi , Yuzuru Ikehara , Takashi Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Ohkura , Toshihide Shikanai , Maki Sogabe , Akira Togayachi , Makoto Ochou , Yasuhito Tanaka , Masashi Mizokami
- 申请人： Hisashi Narimatsu , Jun Hirabayashi , Yuzuru Ikehara , Takashi Angata , Hiroyuki Kaji , Atsushi Kuno , Takashi Ohkura , Toshihide Shikanai , Maki Sogabe , Akira Togayachi , Makoto Ochou , Yasuhito Tanaka , Masashi Mizokami
- 优先权： JP2009-165795 20090714
- 国际申请： PCT/JP2010/061791 WO 20100712
- 主分类号： C40B30/04
- IPC分类号： C40B30/04 ; C07K14/00
摘要：
The present invention is directed to developing a glycan markers capable of detecting a hepatic disease, and more specifically to developing a glycan marker indicating a hepatic disease-state. Furthermore, the present invention is also directed to developing a glycan marker capable of distinguishing hepatic disease-states with the progress of hepatocarcinoma. The present inventors identified, among the serum glycoproteins, glycopeptides and glycoproteins in which a glycan structure specifically changes due to a hepatic diseases including hepatocarcinoma and provide these as novel glycan markers (glycopeptide and glycoprotein) specific to hepatic disease-states.
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