Embodiments of the present invention relate to a thermoplastic polyurethane (“TPU”) infused mesh material that is molded to form at least a portion of a shoe. The TPU infused mesh may be formed as an upper, a portion of sole or other components of a shoe. The TPU infused mesh is formed, in an exemplary embodiment, through the application of liquid TPU to a surface of a spacer mesh. The liquid TPU infused spacer mesh is then cured, cut to a pattern, and heat molded to form a desired portion of the shoe. The heat molded TPU mesh is coupled to other portions of the shoe (e.g., sole) to form an article footwear in an exemplary embodiment.