发明申请
- 专利标题: Poly (ADP-Ribose) Polymerase (PARP) Inhibitors
- 专利标题(中): 聚(ADP-核糖)聚合酶(PARP)抑制剂
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申请号: US13352902申请日: 2012-01-18
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公开(公告)号: US20120122835A1公开(公告)日: 2012-05-17
- 发明人: Anthony R. Gangloff , Andrew John Jennings , Benjamin Jones , Andre A. Kiryanov
- 申请人: Anthony R. Gangloff , Andrew John Jennings , Benjamin Jones , Andre A. Kiryanov
- 申请人地址: JP Osaka
- 专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人地址: JP Osaka
- 主分类号: A61K31/4985
- IPC分类号: A61K31/4985 ; C07D403/14 ; A61K31/53 ; C07D471/04 ; C07D513/14 ; A61K31/542 ; C07D498/14 ; A61K31/5383 ; A61K31/397 ; C07D487/14 ; A61K31/551 ; A61P35/00 ; A61P9/00 ; A61P3/00 ; A61P29/00 ; A61P9/10 ; A61P25/28 ; C07D471/14
摘要:
Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
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