发明申请
US20120122168A1 RECOMBINANT ESCHERICHIA COLI HAVING ENHANCED ACETYL-COENZYME A SYNTHETASE ACTIVITY FOR PRODUCING GLYEROL AND GLYCEROL-DERIVED PRODUCTS
失效
具有增强的乙酰胆碱的重组蛋白合成酶用于生产甘油和甘油衍生产物的合成酶活性
- 专利标题： RECOMBINANT ESCHERICHIA COLI HAVING ENHANCED ACETYL-COENZYME A SYNTHETASE ACTIVITY FOR PRODUCING GLYEROL AND GLYCEROL-DERIVED PRODUCTS
- 专利标题（中）： 具有增强的乙酰胆碱的重组蛋白合成酶用于生产甘油和甘油衍生产物的合成酶活性
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申请号： US12946120申请日： 2010-11-15
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公开(公告)号： US20120122168A1公开(公告)日： 2012-05-17
- 发明人: QI CHEN , QIONG CHENG , ANDREW C. ELIOT , Kristin Ruebling-Jass
- 申请人： QI CHEN , QIONG CHENG , ANDREW C. ELIOT , Kristin Ruebling-Jass
- 申请人地址： US DE WILMINGTON
- 专利权人： E. I. DU PONT DE NEMOURS AND COMPANY
- 当前专利权人： E. I. DU PONT DE NEMOURS AND COMPANY
- 当前专利权人地址： US DE WILMINGTON
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12P7/18 ; C12P7/42 ; C12P7/20
摘要：
Recombinant E. coli having enhanced acetyl-CoA synthetase activity and the ability to produce glycerol and glycerol-derived products, such as 3-hydroxypropionic acid, methylglyoxal, 1,2-propanediol, and 1,3-propanediol, are described. The recombinant E. coli comprise a promoter operably linked to a nucleotide sequence encoding a polypeptide having acetyl-CoA synthetase enzyme activity, wherein the promoter and nucleotide sequence are each independently either native or non-native.
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