发明申请
US20120027679A1 CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME
审中-公开
用于摄影成像的对比剂和使用其的光电成像方法
- 专利标题: CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME
- 专利标题(中): 用于摄影成像的对比剂和使用其的光电成像方法
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申请号: US13112135申请日: 2011-05-20
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公开(公告)号: US20120027679A1公开(公告)日: 2012-02-02
- 发明人: Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Sachiko Inoue , Tatsuki Fukui , Masato Minami , Mayuko Kishi
- 申请人: Fumio Yamauchi , Satoshi Ogawa , Kengo Kanazaki , Sachiko Inoue , Tatsuki Fukui , Masato Minami , Mayuko Kishi
- 申请人地址: JP Tokyo
- 专利权人: CANON KABUSHIKI KAISHA
- 当前专利权人: CANON KABUSHIKI KAISHA
- 当前专利权人地址: JP Tokyo
- 优先权: JP2009-231994 20091005; JP2010-144322 20100624
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; B32B5/16 ; C07K17/14 ; G01N33/574 ; B82Y15/00
摘要:
It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP−((L)l−(P)m)n (Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.
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