In a centrifugal compressor, for the purpose of preventing the positions of a diaphragm and a head flange in a radial direction from moving with respect to a casing, suppressing the generation of an unstable fluid force in a seal and the contact of the seal with a rotor to prevent the unstable vibration of the rotor and enabling an efficient and stable operation even on high-pressure conditions, there is provided a barrel-shaped centrifugal compressor including a casing, a diaphragm located in the casing to define a flow channel, and a head flange attached to the end of the casing by a shear key, wherein in the inner peripheral surface of the casing and the outer peripheral surface of abutment portions of the diaphragm and the head flange in which they are abutted on the inner peripheral surface of the casing, sliding key grooves which are vertical to the surfaces are provided at least two portions in a peripheral direction, and sliding keys are provided in the key grooves.