发明申请
- 专利标题： ACID ADDITION SALT OF UDENAFIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
- 专利标题（中）： 醋酸加入盐，其制备方法及包含其的药物组合物
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申请号： US13201900申请日： 2010-02-17
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公开(公告)号： US20110306762A1公开(公告)日： 2011-12-15
- 发明人: Chan-Ho Lee , Chang-Yong Shin , Seul-Min Choi , Kyung-Koo Kang , Dong-Seong Kim , Byoung-Ok Ahn , Moo-Hi Yoo
- 申请人： Chan-Ho Lee , Chang-Yong Shin , Seul-Min Choi , Kyung-Koo Kang , Dong-Seong Kim , Byoung-Ok Ahn , Moo-Hi Yoo
- 申请人地址： KR Seoul
- 专利权人： Dong-A Pharm. Co., Ltd.
- 当前专利权人： Dong-A Pharm. Co., Ltd.
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2009-0013350 20090218
- 国际申请： PCT/KR10/00976 WO 20100217
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The present invention provides an acid addition salt of Udenafil, a preparation method thereof and a pharmaceutical composition comprising the same. The acid addition salt of Udenafil in which Udenafil is bonded to an organic acid selected from the group consisting of oxalic acid, benzenesulfonic acid, camphorsulfonic acid, cinnamic acid, adipic acid and cyclamic acid, has excellent solubility in an aqueous medium, water stability and crystallinity, thereby being suitably applied for a pharmaceutical composition.
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