Invention Application
US20110275703A1 SUBSTITUTED SPIROKETAL DERIVATIVES AND USE THEREOF AS THERAPEUTIC DRUG FOR DIABETES
审中-公开
取代的螺旋体衍生物及其作为治疗药物用于糖尿病的药物
- Patent Title: SUBSTITUTED SPIROKETAL DERIVATIVES AND USE THEREOF AS THERAPEUTIC DRUG FOR DIABETES
- Patent Title (中): 取代的螺旋体衍生物及其作为治疗药物用于糖尿病的药物
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Application No.: US12375363Application Date: 2007-07-27
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Publication No.: US20110275703A1Publication Date: 2011-11-10
- Inventor: Tsutomu Sato , Kiyofumi Honda , Takahiro Kawai , Koo Hyeon Ahn
- Applicant: Tsutomu Sato , Kiyofumi Honda , Takahiro Kawai , Koo Hyeon Ahn
- Applicant Address: JP Kita-ku, Tokyo
- Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee Address: JP Kita-ku, Tokyo
- International Application: PCT/JP2007/064806 WO 20070727
- Main IPC: A61K31/352
- IPC: A61K31/352 ; A61P3/04 ; A61K31/381 ; A61P3/10 ; C07D493/10 ; C07D409/14

Abstract:
The present invention provides a compound represented by Formula (II): wherein R1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group; Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d): wherein R2 is a C1-6 alkyl group which may be substituted with one or more halogen atoms, a C1-6 alkoxy group which may be substituted with one or more halogen atoms, a C1-3 alkylthio group, a halogen atom, a C1-3 alkylcarbonyl group or a C2-5 alkynyl group which may be substituted with —OR4; R3 is a hydrogen atom or a C1-3 alkyl group; R4 is a hydrogen atom or a C1-3 alkyl group; provided that Ar is a group represented by Formula (a) when R1 is a fluorine atom, methyl group or an ethynyl group, and that R2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical agent, a pharmaceutical composition and so on comprising the compound.
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