A multi-tablet cutting device 10, 100 has a removable tablet holding tray 20, 200, a housing structure 12, 120 and a plurality of vertically movable cutting blades 32, 320. The removable tablet holding tray 20, 200 has a plurality of tablet nests 25, 250. Each nest 25, 250 has two or more levels of beds sized to hold tablets of different sizes or shapes. The housing structure 12, 120 has at least one opening 16A, 16B, 160 to receive the removable tablet holding tray 20, 200. The plurality of vertically movable cutting blades 32, 320 is mounted on a support structure 30, 300 on the inside of the housing above the tablet holding tray 20, 200 above a location where the tablet holding tray 20, 200 is stored. The plurality of cutting blades 32, 320 is aligned above the tablet nests 25, 250 and upon a downwardly directed vertical movement the plurality of cutting blades 32, 320 passes through first slots 80, 800 in the nests 25, 250 aligned with the cutting blades 32, 320. As the blades 32, 320 pass through a geometric center of the nests 25, 250 they cut the tablets held in the nests 25, 250 into halves.