Invention Application
US20110224195A1 HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
有权
作为用于治疗或预防糖尿病的DIPEPTIDYL PEPTIDASE-IV抑制剂的杂环化合物
- Patent Title: HETEROCYCLIC COMPOUNDS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
- Patent Title (中): 作为用于治疗或预防糖尿病的DIPEPTIDYL PEPTIDASE-IV抑制剂的杂环化合物
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Application No.: US12672100Application Date: 2008-08-18
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Publication No.: US20110224195A1Publication Date: 2011-09-15
- Inventor: Tesfaye Biftu , Danqing Feng , Ann E. Weber , Jason M. Cox , Xiaoxia Qian , Jinyou Xu
- Applicant: Tesfaye Biftu , Danqing Feng , Ann E. Weber , Jason M. Cox , Xiaoxia Qian , Jinyou Xu
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- International Application: PCT/US08/09838 WO 20080818
- Main IPC: A61K31/551
- IPC: A61K31/551 ; C07D487/04 ; C07D487/14 ; C07D471/04 ; A61K31/454 ; A61K31/519 ; A61K31/53 ; A61K31/4985 ; A61K31/4545 ; A61K31/437 ; A61P3/10
Abstract:
The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Public/Granted literature
- US08653059B2 Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes Public/Granted day:2014-02-18
Information query
