A diagnosis system and method comprising a handwriting data collection and analysis software and accompanying tools for diagnosing a given condition such as an illness, a mental illness, a physiological condition, a mental or emotional state, medication effect, a personality trait, a skill, an expertise, deception or truth writing. The handwriting of a control group known to have a condition is analyzed in order to determine the detectable characteristic indicators of that group. Such measured indicators comprise spatial, temporal and pressure measures for each writing stroke. The handwriting of a subject is then analyzed to determine if the measured indicators indicate statistically that the subject can be diagnosed with a condition.