Invention Application
- Patent Title: Imaging Agents for Detecting Neurological Disorders
- Patent Title (中): 用于检测神经障碍的成像剂
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Application No.: US13035405Application Date: 2011-02-25
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Publication No.: US20110182812A1Publication Date: 2011-07-28
- Inventor: Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
- Applicant: Anna Katrin Szardenings , Wei Zhang , Hartmuth C. Kolb , Daniel Kurt Cashion , Gang Chen , Dhanalakshmi Kasi , Changhui Liu , Anjana Sinha , Eric Wang , Chul Yu , Umesh B. Gangadharmath , Joseph C. Walsh
- Applicant Address: US PA Malvern
- Assignee: SIEMENS MEDICAL SOLUTIONS USA, INC.
- Current Assignee: SIEMENS MEDICAL SOLUTIONS USA, INC.
- Current Assignee Address: US PA Malvern
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07D513/04 ; C07D231/56 ; C07D487/04 ; C07D471/04 ; C07D413/14 ; C07D401/10 ; C07D401/04 ; A61K49/00 ; A61P43/00 ; A61P25/28

Abstract:
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
Public/Granted literature
- US08691187B2 Imaging agents for detecting neurological disorders Public/Granted day:2014-04-08
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