发明申请
- 专利标题： TETRAHYDROISOQUINOLINE SULFONAMIDE DERIVATIVES, THE PREPARATION THEREOF, AND THE USE OF THE SAME IN THERAPEUTICS
- 专利标题（中）： 四氢喹诺酮磺酰胺衍生物，其制备方法及其在治疗中的应用
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申请号： US12901063申请日： 2010-10-08
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公开(公告)号： US20110028475A1公开(公告)日： 2011-02-03
- 发明人: Juan Antonio DIAZ MARTIN , Maria Dolores JIMENEZ BARGUENO
- 申请人： Juan Antonio DIAZ MARTIN , Maria Dolores JIMENEZ BARGUENO
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： FR0405607 20040525
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/472 ; A61K31/4725 ; A61K31/496 ; A61P25/18 ; A61P25/24 ; A61P25/08 ; A61P25/22 ; A61P1/08 ; A61P25/16 ; A61P25/00 ; A61P25/28 ; A61P15/00 ; A61P3/10 ; A61P3/04
摘要：
The disclosure relates to tetrahydroisoquinoline sulfonamide compounds of formula I: wherein R1, R2, n and B are as defined in the disclosure, their preparation and their use in therapies for the treatment of central nervous system diseases such as vigilance and sleep disorders, narcolepsy, Alzheimer's disease and other dementias, Parkinson's disease, attention disorders in hyperkinetic children, memory and learning disorders, epilepsy, schizophrenia, moderate cognitive disorders, depression, anxiety, sexual dysfunction, dizziness and travel sickness.
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