发明申请
- 专利标题： USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION
- 专利标题（中）： 电子化合物用于诱导电极生产或维持电极功能的用途
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申请号： US12738949申请日： 2008-10-29
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公开(公告)号： US20110027223A1公开(公告)日： 2011-02-03
- 发明人: Richard P. Phipps , Jamie O'Brien
- 申请人： Richard P. Phipps , Jamie O'Brien
- 申请人地址： US NY Rochester
- 专利权人： UNIVERSITY OF ROCHESTER
- 当前专利权人： UNIVERSITY OF ROCHESTER
- 当前专利权人地址： US NY Rochester
- 国际申请： PCT/US08/81565 WO 20081029
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K31/19 ; A61K31/416 ; A61K31/12 ; A61K31/381 ; A61K38/36 ; A61K38/17 ; A61K38/18 ; A61P7/04
摘要：
The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient for low platelet levels, increasing the circulating half-life of platelets, and improving the quality (activity) of platelets are also disclosed herein, which involve administering the electrophilic compound to a patient an effective amount to achieve the desired effect. Pharmaceutical compositions and therapeutic systems are also disclosed for carrying out these therapeutic treatments.
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