This method for acquiring and processing data for detecting the change over time of changing lesions includes: successive data acquisitions according to different acquisition methods, so that, at each moment of acquisition, the user forms a set of data obtained according to respective acquisition methods; storage of the acquired data in a database; and displaying the data by selecting and displaying the selected data on a display screen. During displaying an item of data, the user inserts into an image being displayed at least one matching data item extracted from the database.