发明申请
- 专利标题： y134.5 Deficient HSV and the MAPK Pathway
- 专利标题（中）： y134.5缺血性HSV和MAPK通路
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申请号： US12161763申请日： 2007-01-24
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公开(公告)号： US20100221228A1公开(公告)日： 2010-09-02
- 发明人: Kerrington D. Smith , James J. Mezhir , Ralph Weichselbaum , Bernard Roizman
- 申请人： Kerrington D. Smith , James J. Mezhir , Ralph Weichselbaum , Bernard Roizman
- 申请人地址： US IL Chicago
- 专利权人： The University of Chicago
- 当前专利权人： The University of Chicago
- 当前专利权人地址： US IL Chicago
- 国际申请： PCT/US07/61002 WO 20070124
- 主分类号： A61K35/76
- IPC分类号： A61K35/76 ; A61P35/00 ; C12N7/00
摘要：
The invention provides materials and methods for the identification of cells exhibiting a cell proliferative disorder that are amenable to treatment with a herpes simplex virus that does not express an approximately wild-type level of ICP34.5. Also provided are methods of treating cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.
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