发明申请
US20100183727A1 Immunonanotherapeutics that Provide IgG Humoral Response Without T-Cell Antigen
有权
提供无T细胞抗原的IgG体液应答的免疫疗法
- 专利标题： Immunonanotherapeutics that Provide IgG Humoral Response Without T-Cell Antigen
- 专利标题（中）： 提供无T细胞抗原的IgG体液应答的免疫疗法
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申请号： US12428408申请日： 2009-04-22
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公开(公告)号： US20100183727A1公开(公告)日： 2010-07-22
- 发明人: Matteo Iannacone , Frank Alexis , Pamela Basto , Ashley Moseman , Jinjun Shi , Robert Langer , Omid C. Farokhzad , Ulrich von Andrian
- 申请人： Matteo Iannacone , Frank Alexis , Pamela Basto , Ashley Moseman , Jinjun Shi , Robert Langer , Omid C. Farokhzad , Ulrich von Andrian
- 优先权： USPCT/US08/11932 20081012
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K39/00 ; A61P37/04
摘要：
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
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