发明申请
- 专利标题： HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER
- 专利标题（中）： 含有氮原子或其药学上可接受的盐的杂环化合物，其制备方法和包括其治疗癌症的药物组合物
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申请号： US12376889申请日： 2007-08-10
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公开(公告)号： US20100144708A1公开(公告)日： 2010-06-10
- 发明人: Gyoon Hee Han , Eun Hyun Choi , Jee Sun Yang , Sung Hee Hong , Myung Sook Kim , Mi Sun Won , Kyung Sook Chung , Dong Myung Kim , Hyang Sook Yoo , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Youn Woong Choi , Yong Mi Jeong , Byung Gu Min
- 申请人： Gyoon Hee Han , Eun Hyun Choi , Jee Sun Yang , Sung Hee Hong , Myung Sook Kim , Mi Sun Won , Kyung Sook Chung , Dong Myung Kim , Hyang Sook Yoo , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Youn Woong Choi , Yong Mi Jeong , Byung Gu Min
- 申请人地址： KR Daejeon KR Seoul
- 专利权人： Korea Research Instititute of Bioscience and Biotechnology,Seoul Pharma, Co., Ltd.
- 当前专利权人： Korea Research Instititute of Bioscience and Biotechnology,Seoul Pharma, Co., Ltd.
- 当前专利权人地址： KR Daejeon KR Seoul
- 优先权： KR10-2006-0075827 20060810
- 国际申请： PCT/KR2007/003861 WO 20070810
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D243/08 ; C07D211/96 ; A61K31/4965 ; A61P35/04
摘要：
The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.
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