发明申请
US20100076014A1 MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
有权
GLUCOCORTICOID受体的调节剂，AP-1和/或NF-kB活性及其用途
- 专利标题： MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
- 专利标题（中）： GLUCOCORTICOID受体的调节剂，AP-1和/或NF-kB活性及其用途
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申请号： US12513192申请日： 2007-10-31
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公开(公告)号： US20100076014A1公开(公告)日： 2010-03-25
- 发明人: James E. Sheppeck , John l. Gilmore , T.G. Murali Dhar , Hai-Yun Xiao
- 申请人： James E. Sheppeck , John l. Gilmore , T.G. Murali Dhar , Hai-Yun Xiao
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 国际申请： PCT/US07/83084 WO 20071031
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; C07D417/12 ; C07D417/14 ; C07D401/12 ; C07D471/04 ; A61K31/433 ; A61K31/4439 ; A61K31/454 ; A61K31/437 ; A61P3/00 ; A61P29/00 ; A61P37/00
摘要：
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, and/or AP-1, and/or NF-κB activity including inflammatory and immune diseases, obesity and diabetes having the structure of formula (I), its enantiomers, diastereomers, or a pharmaceutically-acceptable salt, or hydrate, thereof, wherein (Ia) is heterocycle or heteroaryl; J, Ja, E, F, G, Ma, M, Q, Za and Z are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
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