- 专利标题: ORGANIC COMPOUNDS
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申请号: US12483599申请日: 2009-06-12
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公开(公告)号: US20090253703A1公开(公告)日: 2009-10-08
- 发明人: Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
- 申请人: Daniel Kaspar Baeschlin , Juergen Klaus Maibaum , Holger Sellner
- 主分类号: A61K31/165
- IPC分类号: A61K31/165 ; A61K31/4453 ; A61K31/5375 ; A61P9/12
摘要:
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
公开/授权文献
- US07919529B2 δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amides 公开/授权日:2011-04-05
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