发明申请
- 专利标题: PROCESS TO MINIMIZE POLYMORPHISM
- 专利标题(中): 最小化多态性的过程
-
申请号: US12393584申请日: 2009-02-26
-
公开(公告)号: US20090226522A1公开(公告)日: 2009-09-10
- 发明人: Simon A.M. Howes , Rosie McLaughlin , Andrew Jordan , Wei Tian
- 申请人: Simon A.M. Howes , Rosie McLaughlin , Andrew Jordan , Wei Tian
- 主分类号: A61K9/10
- IPC分类号: A61K9/10 ; A61K31/551 ; A61K31/5517
摘要:
The commercial formulation of fast dispersing dosage forms (FDDF) requires substantial holding times during which large quantities of pharmaceutically active substance are formed into individual dosage units. During this holding time, pharmaceutical agents with a propensity to polymorphism in an aqueous environment may crystallize into various, and sometimes unpredictable forms. These crystalline forms may affect the efficacy of the pharmaceutical agent. Previous attempts to control this process have included attempts to direct crystallization into a stable form. The instant invention acts to suppress crystallization, by utilizing a combination of standard molecular weight fish gelatin and a low processing temperature, to suppress crystallization to a degree that is not accomplished by either the use of standard molecular weight fish gelatin or low processing temperatures individually.
信息查询