发明申请
- 专利标题: Ligand for Vesicular Acetylcholine Transporter
- 专利标题(中): 水囊乙酰胆碱转运蛋白配体
-
申请号: US11887580申请日: 2006-03-31
-
公开(公告)号: US20090163461A1公开(公告)日: 2009-06-25
- 发明人: Kazuhiro Shiba , Kiichi Ishiwata , Hideo Tsukada , Shingo Nishiyama
- 申请人: Kazuhiro Shiba , Kiichi Ishiwata , Hideo Tsukada , Shingo Nishiyama
- 优先权: JP2005-106824 20050401
- 国际申请: PCT/JP2006/307418 WO 20060331
- 主分类号: A61K31/555
- IPC分类号: A61K31/555 ; C07D211/22 ; C07F15/00 ; A61K31/445
摘要:
The present invention provides a novel compound represented by the formula (I): wherein R1 and R2 are as defined in the specification, or a salt thereof, which is useful as a reagent (radiotracer) for VAChT mapping and the like, and can be used for positron emission tomography (PET), and a production method of the compound. Moreover, the present invention provides a diagnostic reagent for diagnosing cholinergic neurodegenerative disorders (e.g., Alzheimer's disease, memory disorder, learning disorder, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgia, Parkinson's disease and the like) and the like, which contains the aforementioned compound.
信息查询