A power generation system includes at least one turbine system comprising a compressor section configured to supply a first portion and a second portion of compressed oxidant and an oxidant booster to further boost pressure of the first portion of compressed oxidant to generate a high pressure oxidant. The power generation system further includes a partial oxidation unit configured to receive the high pressure oxidant and a compressed fuel to generate a high pressure fuel stream and a CO2 separation system fluidly coupled to the partial oxidation unit for receiving the high pressure fuel stream and provide a CO2 lean fuel stream. A syngas expander is configured to receive the CO2 lean fuel stream to utilize the energy content in the CO2 lean fuel stream to generate a partially expanded fuel stream and a combustion chamber is configured to combust the second portion of compressed oxidant and the partially expanded fuel stream to generate a hot flue gas. An expander section is provided having an inlet for receiving the hot flue gas configured to generate electrical energy and an expanded exhaust gas lean in CO2.