发明申请
US20090155834A1 METHODS FOR IDENTIFYING AGENTS WHICH ALTER HISTONE PROTEIN ACETYLATION, DECREASE AGING OR INCREASE LIFESPAN
有权
用于鉴定肝细胞蛋白质乙酰化,降解衰老或增加生殖激素的药剂的方法
- 专利标题: METHODS FOR IDENTIFYING AGENTS WHICH ALTER HISTONE PROTEIN ACETYLATION, DECREASE AGING OR INCREASE LIFESPAN
- 专利标题(中): 用于鉴定肝细胞蛋白质乙酰化,降解衰老或增加生殖激素的药剂的方法
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申请号: US12209847申请日: 2008-09-12
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公开(公告)号: US20090155834A1公开(公告)日: 2009-06-18
- 发明人: LEONARD GUARENTE , SHIN-ICHIRO IMAI , CHRISTOPHER ARMSTRONG
- 申请人: LEONARD GUARENTE , SHIN-ICHIRO IMAI , CHRISTOPHER ARMSTRONG
- 申请人地址: US MA CAMBRIDGE
- 专利权人: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址: US MA CAMBRIDGE
- 主分类号: C12Q1/02
- IPC分类号: C12Q1/02 ; C12N9/00
摘要:
Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which alter the life span or aging of a cell or an organism by determining the level of NAD-dependent acetylation and/or ADP ribosylation of a nuclear protein. The invention also relates to a mammalian Sir2 protein which acetylates or deacetylates nuclear proteins in a NAD-dependent manner and has mono-ADP-ribosyltransferase activity. Host cells producing the Sir2 protein and antibodies to the Sir2 protein are also provided.
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