发明申请
- 专利标题： Phosphodiesterase 10 inhibitors
- 专利标题（中）： 磷酸二酯酶10抑制剂
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申请号： US11713234申请日： 2007-02-28
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公开(公告)号： US20090099175A1公开(公告)日： 2009-04-16
- 发明人: Mark P. Arrington , Allen T. Hopper , Richard D. Conticello , Truc M. Nguyen , Hans-Jurgen E. Hess , Carla Maria Gauss , Stephen A. Hitchcock
- 申请人： Mark P. Arrington , Allen T. Hopper , Richard D. Conticello , Truc M. Nguyen , Hans-Jurgen E. Hess , Carla Maria Gauss , Stephen A. Hitchcock
- 主分类号： A61K31/502
- IPC分类号： A61K31/502 ; C07D237/28 ; C07D237/30 ; C07D471/04 ; C07D401/04 ; A61K31/506 ; A61K31/5377 ; C07D403/04 ; C07D401/14 ; C07D413/04 ; A61P25/00
摘要：
The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
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