发明申请
- 专利标题: PYRIDYL ACETIC ACID COMPOUNDS
- 专利标题(中): 吡咯烷酮酸化合物
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申请号: US11817088申请日: 2006-02-24
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公开(公告)号: US20090088419A1公开(公告)日: 2009-04-02
- 发明人: Hironobu Maezaki , Nobuhiro Suzuki
- 申请人: Hironobu Maezaki , Nobuhiro Suzuki
- 申请人地址: JP Osaka-shi, Osaka
- 专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- 当前专利权人地址: JP Osaka-shi, Osaka
- 优先权: JP2005-052018 20050225
- 国际申请: PCT/JP2006/304177 WO 20060224
- 主分类号: C07D213/02
- IPC分类号: C07D213/02 ; A61K31/4439 ; C07D401/02 ; A61K31/445 ; A61K31/496 ; A61P3/10 ; A61K31/4545 ; A61K31/551 ; A61K31/55
摘要:
The present invention provides a compound represented by the formula (I): wherein R1 is a C?1-6#191 alkyl group optionally substituted by a C?3-10#191 cycloalkyl group, R2 is a C?2-6#191 alkyl group, R3 is a hydrogen atom, a C?1-6#191 alkyl group or a halogen atom, and X is —OR6 or —NR4R5 wherein R4 and R6 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R5 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted hydroxy group, or R4 and R5 optionally form, together with the adjacent nitrogen atom, an optionally substituted nitrogen-containing heterocycle, or a salt thereof. The compound of the present invention has a superior peptidase inhibitory action and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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