A detachable connection mechanism is to establish an electrical connection between a mobile phone and a notebook computer. The detachable connection mechanism is designed at a housing board. The housing board has an opening. A load board is pivotally connected with the housing board, and in contact with or away from the housing board in parallel. When the load board is in contact with the housing board, the load board is fitted within the opening. Two rotatable members are pivotally connected with housing board. Several resilient arms are respectively pivotally connected with the housing board at one end and with the load board at the other end. The mobile phone is selectively connected or disconnected with the notebook computer by interacting the rotatable members, movable members, resilient arms and the load board.