A printing unit of a web-fed rotary printing press with several printing couples is disclosed. Each printing couple features a transfer cylinder, a plate cylinder, an inking couple and preferably a dampening unit, where the transfer cylinder, the plate cylinder, and rollers of the inking couple and if applicable of the dampening unit of each printing couple, are coupled on the drive side via gears and jointly positioned on side walls of the printing unit. Independently driven ink fountain rollers of the inking couples together with an ink fountain as well as a film roller of the inking couples are positioned on separate side walls in such a way that, in the region of each printing couple, the ink fountain roller, the ink fountain as well as the film roller of the respective inking couple are displaceable relative to the cylinders and rollers of the printing couples.