发明申请
US20080279846A1 METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS
审中-公开
治疗和预防神经病变疾病和疾病的方法
- 专利标题： METHODS OF TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES AND DISORDERS
- 专利标题（中）： 治疗和预防神经病变疾病和疾病的方法
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申请号： US12118973申请日： 2008-05-12
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公开(公告)号： US20080279846A1公开(公告)日： 2008-11-13
- 发明人: Yi SHI , Robert NAGELE
- 申请人： Yi SHI , Robert NAGELE
- 申请人地址： US PA Philadelphia US NJ New Brunswick
- 专利权人： THOMAS JEFFERSON UNIVERSITY,UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
- 当前专利权人： THOMAS JEFFERSON UNIVERSITY,UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
- 当前专利权人地址： US PA Philadelphia US NJ New Brunswick
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K48/00 ; A61K31/517 ; A61K31/519 ; A61K39/00 ; A61P25/00 ; A61K31/55 ; A61K31/4709 ; A61K38/02
摘要：
The present invention provides compostions and methods useful for treating and preventing neurodegenerative disease and neurologically related disorders by inhibition of Lp-PLA2. The compositions and methods are useful for treating and preventing diseases and disorders with abnormal blood brain barrier (BBB) function, for example neurodegenerative diseases with a permeable BBB, such as but not limited to, Alzheimer's Disease, Huntington's Disease, Parkinson's Disease and Vascular Dementia.
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