发明申请
US20080254100A1 METHODS OF USING GAMMA CYCLODEXTRIN TO CONTROL BLOOD GLUCOSE AND INSULIN SECRETION
失效
使用GAMMA CYCLODEXTRIN控制血糖和胰岛素分泌的方法
- 专利标题: METHODS OF USING GAMMA CYCLODEXTRIN TO CONTROL BLOOD GLUCOSE AND INSULIN SECRETION
- 专利标题(中): 使用GAMMA CYCLODEXTRIN控制血糖和胰岛素分泌的方法
-
申请号: US12133669申请日: 2008-06-05
-
公开(公告)号: US20080254100A1公开(公告)日: 2008-10-16
- 发明人: Chron-Si Lai , JoMay Chow , Bryan W. Wolf
- 申请人: Chron-Si Lai , JoMay Chow , Bryan W. Wolf
- 申请人地址: US IL Abbott Park
- 专利权人: ABBOTT LABORATORIES
- 当前专利权人: ABBOTT LABORATORIES
- 当前专利权人地址: US IL Abbott Park
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K31/724 ; A61P3/10
摘要:
Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non-diabetic patients, to prevent reactive hypoglycemia in susceptible non-diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.
公开/授权文献
信息查询