发明申请
US20080160496A1 Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor
审中-公开
保留的可行软骨,其保存方法及其使用的系统和设备
- 专利标题: Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor
- 专利标题(中): 保留的可行软骨,其保存方法及其使用的系统和设备
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申请号: US11884767申请日: 2006-02-22
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公开(公告)号: US20080160496A1公开(公告)日: 2008-07-03
- 发明人: Victor Rzepakovsky , Ginadi Shaham , Udi Damari , Sachi Norman , Peter Bartal
- 申请人: Victor Rzepakovsky , Ginadi Shaham , Udi Damari , Sachi Norman , Peter Bartal
- 国际申请: PCT/IL2006/000231 WO 20060222
- 主分类号: A01N1/02
- IPC分类号: A01N1/02 ; A61F2/02 ; A61B17/32 ; A61B19/00
摘要:
The present invention provides methods for providing cartilage-containing tissue for grafting, comprising providing excised cartilage-containing tissue; and treating said excised cartilage-containing and cryogenically preserving the treated cartilage-containing tissue under appropriate cryogenic preservation conditions so as to yield cryogenically preserved cartilage-containing tissue having at least 10% viable chondrocytes throughout the cartilage portion of the cartilage-containing tissue after preservation, as tested in a live/dead ratio assay. Treatment may comprise providing one or a plurality of incisions in said cartilage portion to a predetermined depth therein and/or introducing a cryoprotectant agent at least into said cartilage portion. The invention also provides viable cartilage obtainable by the methods of the invention, methods of grafting such preserved, viable cartilage containing tissue in a recipient, as well as apparatuses, vessels and systems for preparing a cartilage-containing tissue for cryogenic preservation and subsequent grafting in a recipient.
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