Normalization of regions of a sensor panel capable of detecting multi-touch events, or a sensor panel capable of detecting multi-hover events, is disclosed to enable each sensor in the sensor panel to trigger a virtual button in a similar manner, given the same amount of touch or hover. Each sensor produces an output value proportional to the level or amount of touch or hover. However, due to processing, manufacturing and physical design differences, the sensor output values can vary from region to region or panel to panel for a given amount of touch or hover. To normalize the sensor output values across regions, gain and offset information can be obtained in advance, stored in nonvolatile memory, and later used to normalize the sensor output values so that all regions in the sensor panel can trigger virtual buttons similarly, providing a uniform “response function” at any location on the sensor panel.