Invention Application
US20080070869A1 Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
审中-公开
用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
- Patent Title: Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
- Patent Title (中): 用作代谢调节剂的丙二酰辅酶A脱羧酶抑制剂
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Application No.: US11855984Application Date: 2007-09-14
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Publication No.: US20080070869A1Publication Date: 2008-03-20
- Inventor: Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
- Applicant: Thomas Arrhenius , Mi Chen , Jie Fei Cheng , Yujin Huang , Alex Nadzan , Sovouthy Tith , David Wallace , Bin Liu , Masahiro Nishimoto , Gary Lopaschuk , Jason Dyck
- Applicant Address: JP Tokyo 115-8543
- Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee Address: JP Tokyo 115-8543
- Main IPC: A61K31/66
- IPC: A61K31/66 ; A61K31/155 ; A61K31/185 ; A61P3/10 ; A61P9/00 ; A61P35/00 ; A61P3/04 ; A61K31/277
Abstract:
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
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