Invention Application
- Patent Title: Novel Cyclic Amino Benzoic Acid Derivative
- Patent Title (中): 新型环状氨基苯甲酸衍生物
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Application No.: US11659854Application Date: 2005-08-11
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Publication No.: US20070249580A1Publication Date: 2007-10-25
- Inventor: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- Applicant: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- Priority: JP2004-234603 20040811
- International Application: PCT/JP05/14718 WO 20050811
- Main IPC: A61K31/426
- IPC: A61K31/426 ; A61K31/445 ; A61K31/5375 ; A61K31/55 ; A61P3/10 ; C07D211/36 ; C07D223/00 ; C07D277/02 ; C07D413/00

Abstract:
The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US07902367B2 Cyclic amino benzoic acid derivative Public/Granted day:2011-03-08
Information query
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