发明申请
US20070213536A1 Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
失效
顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映异构体富集方法
![Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane](/docs/US/2007-09-13/US20070213536A1/abs.jpg.600x600.jpg)
- 专利标题： Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
- 专利标题（中）： 顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映异构体富集方法
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申请号： US11651309申请日： 2007-01-09
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公开(公告)号： US20070213536A1公开(公告)日： 2007-09-13
- 发明人: Herbert Diehl , Andreas Krebs , Elvira Krebs , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
- 申请人： Herbert Diehl , Andreas Krebs , Elvira Krebs , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
- 优先权： DE10226923.8 20020617
- 主分类号： C07D471/02
- IPC分类号： C07D471/02
![Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane](/abs-image/US/2007/09/13/US20070213536A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed). In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
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