A multi-band multi-mode wireless communication device comprises a first antenna, a second antenna, a first transmitter circuit corresponding to the FDD system, a first receiver circuit and a second receiver circuit, a first transmitter circuit and a third receiver circuit corresponding to the TDD system, a duplexer, an SP3T switch, and a base-band signal processor. The second transmitter circuit, third receiver circuit and duplexer are connected with each other via the first antenna and the SP3T switch, the duplexer is connected to the first transmitter circuit and the first receiver circuit, and the second antenna is connected to the second receiver circuit. The received signals corresponding to the FDD system received by the first and second antennas are inputted to the base-band signal processor via the first and second receiver circuits and are then synthesized therein.