发明申请
- 专利标题: Benzimidazole compound
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申请号: US11403815申请日: 2006-04-14
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公开(公告)号: US20070015782A1公开(公告)日: 2007-01-18
- 发明人: Shuhei Miyazawa , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
- 申请人: Shuhei Miyazawa , Masanobu Shinoda , Tetsuya Kawahara , Nobuhisa Watanabe , Hitoshi Harada , Daisuke Iida , Hiroki Terauchi , Junichi Nagakawa , Hideaki Fujisaki , Atsuhiko Kubota , Masato Ueda
- 专利权人: Eisai Co., Ltd.
- 当前专利权人: Eisai Co., Ltd.
- 优先权: JP2005-117643 20050415
- 主分类号: A61K31/4747
- IPC分类号: A61K31/4747 ; A61K31/4439 ; C07D491/14
摘要:
An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.
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