A physiologically ingestible composition of matter obtained by preparing oxygenated water with a stable negative oxidation reduction potential (ORP), and the uses thereof, are provided. The obtaining method includes preconditioning water received from a water source for electrolysis, performing electrolysis on the preconditioned water, outputting alkaline water and/or acidic water with a stable negative ORP (“negative ORP water”), combining the negative ORP water with oxygen, and manipulating the combined negative ORP water and oxygen into a vortex so as to cause the oxygen to diffuse into the water. The output alkaline and/or acidic oxygenated water with a stable negative ORP may be used for a variety of purposes and/or applications. For example, the method may be utilized as part of a method for producing and tuning super-oxygenated and structured water. The physiologically ingestible composition of matter may be administered to reduce fatigue in a mammal.