发明申请
US20060217440A1 Porcess for production of 2-cyano-3-hydroxy-n-(4-trifluoromethylphenyl)hept-2-en-6-ynamide and process for production of polymorphs thereof
审中-公开
2-氰基-3-羟基 - 正（4-三氟甲基苯基）庚-2-烯-6-基酰胺的生产工艺及其多晶型物的制备方法
- 专利标题： Porcess for production of 2-cyano-3-hydroxy-n-(4-trifluoromethylphenyl)hept-2-en-6-ynamide and process for production of polymorphs thereof
- 专利标题（中）： 2-氰基-3-羟基 - 正（4-三氟甲基苯基）庚-2-烯-6-基酰胺的生产工艺及其多晶型物的制备方法
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申请号： US10550099申请日： 2004-03-23
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公开(公告)号： US20060217440A1公开(公告)日： 2006-09-28
- 发明人: Hiroki Omori , Satoshi Hirabayashi , Ariyoshi Kubota , Takeshi Kawakami , Yosuke Fujii , Ikuo Matsumoto , Masato Kitayama , Shunsuke Goto
- 申请人： Hiroki Omori , Satoshi Hirabayashi , Ariyoshi Kubota , Takeshi Kawakami , Yosuke Fujii , Ikuo Matsumoto , Masato Kitayama , Shunsuke Goto
- 优先权： JP2003-081335 20030324; JP2003-176706 20030620
- 国际申请： PCT/JP04/03904 WO 20040323
- 主分类号： A61K31/277
- IPC分类号： A61K31/277 ; C07C253/30
摘要：
A compound (II) is reacted with a compound (III) or a reactive derivative at the carboxyl group thereof to obtain a compound (IV), which is reacted with a mixed acid anhydride of a compound (V) to prepare a compound (I). In recrystallization of the compound (I), temperature for the recrystallization and/or time for the crystal precipitation is controlled to selectively produce A-form crystals, B-form crystals and C-form crystals of the compound (I).
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