- 专利标题: Tumor associated antigen peptides and use of same as anti-tumor vaccines
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申请号: US11391476申请日: 2006-03-29
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公开(公告)号: US20060194730A1公开(公告)日: 2006-08-31
- 发明人: Lea Eisenbach , Lior Carmon , Boaz Tirosh , Erez Bar-Haim , Adrian Paz , Matityahu Fridkin , Cheryl Fitzer-Attas
- 申请人: Lea Eisenbach , Lior Carmon , Boaz Tirosh , Erez Bar-Haim , Adrian Paz , Matityahu Fridkin , Cheryl Fitzer-Attas
- 申请人地址: IL Rehovot
- 专利权人: YEDA RESEARCH AND DEVELOPMENT CO. Ltd.
- 当前专利权人: YEDA RESEARCH AND DEVELOPMENT CO. Ltd.
- 当前专利权人地址: IL Rehovot
- 优先权: IL125608 19980730
- 主分类号: A61K38/17
- IPC分类号: A61K38/17 ; A61K39/00 ; C07K14/82
摘要:
The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides derived from Uroplakin Ia, Ib, II and III, Prostate specific antigen (PSA), Prostate acid phosphatase (PAP) and Prostate specific membrane antigen (PSMA), BA-46 (Lactadherin), Mucin (MUC-1), and Teratocarcinoma-derived growth factor (CRIPTO-1) and the use of same as anti-tumor vaccines to prevent or cure bladder, prostate, breast or other cancers, carcinomas in particular. Most particularly, the present invention relates to tumor associated antigen peptides which are presentable to the immune system by HLA-A2 molecules.
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