发明申请
- 专利标题： Method for sustaining enos activity
- 专利标题（中）： 维持enos活动的方法
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申请号： US10537599申请日： 2003-12-04
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公开(公告)号： US20060127385A1公开(公告)日： 2006-06-15
- 发明人: Sibaji Sarkar , Jane Freedman , Sonia Varghese
- 申请人： Sibaji Sarkar , Jane Freedman , Sonia Varghese
- 申请人地址： US MA Boston
- 专利权人： The Trustees of Boston University
- 当前专利权人： The Trustees of Boston University
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US03/38374 WO 20031204
- 主分类号： A61K38/54
- IPC分类号： A61K38/54
摘要：
The present invention is directed to methods for sustaining eNOS activity to inhibit platelet aggregation, clot retraction, and enhance fibrinolysis. One embodiment of the invention provides methods of treating thrombosis by inhibiting the activity of the syk kinase. Another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by screening for compounds which sustain eNOS activity. Yet another embodiment provides assays for the discovery of improved compounds to treat thrombosis, by identifying inhibitors of calpain and IIbIIIa by screening for compounds which act through calpain or IIbIIIa to sustain eNOS activity. Yet another embodiment provides for enhancing fibrinolysis, by inhibiting the activity of the syk kinase or calpain.
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