Invention Application
US20060111294A1 Use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells
审中-公开
使用多肽结构域来调节癌细胞的致瘤和转移潜能
- Patent Title: Use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells
- Patent Title (中): 使用多肽结构域来调节癌细胞的致瘤和转移潜能
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Application No.: US11269070Application Date: 2005-11-07
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Publication No.: US20060111294A1Publication Date: 2006-05-25
- Inventor: Hilde Revets , Patrick De Baetselier , Nick Devoogdt , Gholamreza Hassanzadeh Ghassabeh
- Applicant: Hilde Revets , Patrick De Baetselier , Nick Devoogdt , Gholamreza Hassanzadeh Ghassabeh
- Applicant Address: BE Zwijnaarde BE Brussel
- Assignee: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW,Vrije Universiteit Brussel
- Current Assignee: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW,Vrije Universiteit Brussel
- Current Assignee Address: BE Zwijnaarde BE Brussel
- Priority: EP03101265.1 20030507
- Main IPC: A61K38/17
- IPC: A61K38/17 ; G01N33/574
Abstract:
The present invention relates to the use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells. More specifically, the present invention relates to a domain of a Secretory Leukocyte Protease Inhibitor (SLPI) to modulate tumor invasiveness and/or metastasis. It further relates to compounds, such as antibodies, that interact with said domain and repress the tumor invasiveness and/or the metastasis.
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