发明申请
- 专利标题: Furan or thiopene derivative and medicinal use thereof
- 专利标题(中): 呋喃或噻吩衍生物及其医药用途
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申请号: US10526507申请日: 2003-09-04
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公开(公告)号: US20060100261A1公开(公告)日: 2006-05-11
- 发明人: Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
- 申请人: Kazumasa Hamamura , Shigekazu Sasaki , Yuichiro Amano , Junichi Sakamoto , Kohji Fukatsu
- 申请人地址: JP OSAKA 541-0045
- 专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED INTELLECTUAL PROPERTY DEPARTMENT
- 当前专利权人: TAKEDA PHARMACEUTICAL COMPANY LIMITED INTELLECTUAL PROPERTY DEPARTMENT
- 当前专利权人地址: JP OSAKA 541-0045
- 优先权: JP2002-261873 20020906; JP2003-185241 20030627
- 国际申请: PCT/JP03/11308 WO 20030904
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/381 ; A61K31/34 ; C07D333/22 ; C07D207/30
摘要:
The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(═O)—N(R3)— or —N(R3)—C(═O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.
公开/授权文献
- US07553867B2 Furan or thiophene derivative and medicinal use thereof 公开/授权日:2009-06-30
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