发明申请
- 专利标题： Protein kinase modulators and method of use
- 专利标题（中）： 蛋白激酶调节剂及其使用方法
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申请号： US11126000申请日： 2005-05-09
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公开(公告)号： US20060009453A1公开(公告)日： 2006-01-12
- 发明人: Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
- 申请人： Stephanie Geuns-Meyer , Brian Hodous , Stuart Chaffee , Paul Tempest , Philip Olivieri , Rebecca Johnson , Brian Albrecht , Vinod Patel , Victor Cee , Joseph Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nguyen , Holly Deak
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; A61K31/506 ; C07D43/14
摘要：
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
公开/授权文献
- US07880000B2 Protein kinase modulators and method of use 公开/授权日：2011-02-01
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