发明申请
- 专利标题： PHARMACEUTICALS FOR THE IMAGING OF ANGIOGENIC DISORDERS
- 专利标题（中）： 用于成像发生疾病的药物
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申请号： US10622246申请日： 2003-07-18
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公开(公告)号： US20060003926A1公开(公告)日： 2006-01-05
- 发明人: Milind Rajopadhye , D. Edwards , John Barrett , Alan Carpenter , Thomas Harris , Stuart Heminway , Shuang Liu , Singh Prahlad
- 申请人： Milind Rajopadhye , D. Edwards , John Barrett , Alan Carpenter , Thomas Harris , Stuart Heminway , Shuang Liu , Singh Prahlad
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; C07K7/64
摘要：
The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
公开/授权文献
- US07052673B2 Pharmaceuticals for the imaging of angiogenic disorders 公开/授权日：2006-05-30
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